Thomas Meade


PhD, Ohio State University

Chemistry
Interdisciplinary Biological Sciences Program
Department of Molecular Biosciences
Neurobiology
Biomedical Engineering
Radiology

Office Phone: 847.491.2481
Email
Meade Group

Research

Our research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research efforts and can be divided into the three areas: Biological Molecular Imaging: We design and synthesize spectroscopic and magnetic probes that incorporate novel functionality for magnetic resonance and fluorescence in vivo microscopic imaging of biological systems. Particular emphasis is on answering questions about gene expression, nerve patterning, regulation of cell lineage, and DNA transfection. In order to understand how assemblies and patterns of cells in developing tissues originate from an initially homogeneous state we employ optical and magnetic resonance imaging (MRI) techniques that are enhanced by the development of contrast agents to understand these processes. The goal of this work is to develop new classes of biochemically activated contrast agents capable of reporting on the anatomical and physiological function of cellular processes in experimental animals.

Metal Complexes as Enzyme Inhibitors: The use of metals in medicine has grown impressively in recent years as the result of a greatly advanced understanding of the structures of biologically active metal complexes and metal-containing proteins. This area of research focuses on the interaction of inorganic therapeutic agents that can be specifically coupled to a biologically active site by cooperative redox-binding ligation. The strategy employs a series of transition metal complexes capable of irreversible inactivation of a selected enzymatic target and will be used in the development of new classes of therapeutic antitumor and antiviral agents. This work involves a two-pronged approach that is based on our ability to design site-specific ligands and then to fine tune the redox potentials of the reagent.

 

Publications

Rammohan N; Holbrook RJ; Rotz MW; MacRenaris KW; Preslar AT;  Carney CE; Reichova V; Meade TJ. “Gd(III)-Gold Nanoconjugates Provide Remarkable Cell Labeling for High Field MR Imaging” (2016) BioConj Chem. In Press

Preslar AT, Tantakitti F, Park KE, Zhang S, Stupp S, Meade TJ. “19F-Magnetic Resonance Imaging Signals from Peptide Amphiphile Nanostructures are Strongly Affected by their Shape" ACS Nano (2016). [Epub ahead of print]  PMCID in process.

Holbrook RJ, Rammohan N, Rotz MW, MacRenaris KW, Preslar AT, Meade TJ.” Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas,” Nano Letters (2016), 16(5), 3202-3209.  Epub 2016 Apr 20. PMCID in process.

Hung AH, Lilley LM, Hu F, Harrison VS, Meade TJ. “Magnetic barcode imaging for contrast agents.” Magn Reson Med. (2016) Apr 8. doi: 10.1002/mrm.26175. [Epub ahead of print] PMCID in process.

MacRenaris KW, Zhidong M, Krueger RL, Carney CE, Meade TJ. “Cell Permeable Esterase-Activated Ca(II)-Sensitive MRI Contrast Agent” Bioconjugate Chemistry, (2016) Bioconjug Chem. (2016) Feb 17; 27(2): 465–473. PMCID: PMC4776747.

Vistain LF, Rotz MW, Rathore R, Preslar AT, Meade TJ. “Targeted Delivery of Gold Nanoparticle Contrast Agents for Reporting Gene Detection by Magnetic Resonance Imaging” ChemComm, (2015), Dec 15;52(1):160-3. PMCID: PMC4679476.

Heffern MC, Reichova V, Coomes J, Harney A, Bajema EA, Meade TJ. “Tuning Cobalt(III) Schiff Base Complexes as Activated Protein Inhibitors.” Inorg Chem. 2015 Sep 21; 54(18): 9066–9074. PMCID: PMC4638226

Carney CE, MacRenaris KW, Meade TJ. “Water-Soluble Lipophilic MR Contrast Agents for Cell Membrane Labeling” Journal of Biological Inorganic Chemistry (2015) 2015 Sep;20(6):971-7. PMCID: PMC4546878

Vistain LF, Yamamoto N, Rathore R, Cha P, Meade TJ.  “Targeted inhibition of Snail activity in breast cancer cells using a Co(III)-Ebox conjugate” Chembiochem. 2015 Sep; 16(14): 2065–2072.   PMCID: PMC4638217

Harrison VSR, Carney CE, Macrenaris KW, Waters EA, Meade TJ,  "A Multimeric Near IR-MR Contrast Agent for Multimodal In Vivo Imaging" J Am Chem Soc. (2015) Jul 22;137(28):9108-16.  PMCID: PMC4512902

Links

View all publications by publications by Thomas J. Meade listed in the National Library of Medicine (PubMed).

Recent Photos

August 12, 2016