PhD, Northwestern University
Dr. Horvath’s research focuses on signal transduction and gene expression in the mammalian innate immune and inflammatory cytokine responses to infection and cancer. The group is examining both the activation and propagation of cellular signaling pathways and the general and gene-specific phenomena controlling inducible transcriptional regulation in human cells. Our research projects on signaling and gene regulation include molecular, biochemical, and physical approaches to understand fundamental mechanisms underlying human immune recognition and response. This includes single molecule and ensemble experiments designed to examine protein-nucleic acids in a variety of cellular contexts. Recent projects also use next-generation sequencing and high-throughput approaches to solve mechanistic questions and identify novel vulnerabilities for controlling signal transduction and gene regulation.
- Neapolitan R, Horvath CM, Jiang X. Pan-cancer analysis of TCGA data reveals notable signaling pathways. BMC Cancer. 2015 Jul 14;15:516. doi: 10.1186/s12885-015-1484-6. PubMed PMID: 26169172; PubMed Central PMCID:PMC4501083.
- Tell RW, Horvath CM. Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12787-92. doi: 10.1073/pnas.1404881111. Epub 2014 Aug 19. PubMed PMID: 25139989; PubMed Central PMCID: PMC4156751.
- Bruns AM, Leser GP, Lamb RA, Horvath CM. The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Mol Cell. 2014 Sep 4;55(5):771-81. doi: 10.1016/j.molcel.2014.07.003. Epub 2014 Aug 7. PubMed PMID: 25127512; PubMed Central PMCID: PMC4156907.
- Freaney JE, Zhang Q, Yigit E, Kim R, Widom J, Wang JP, Horvath CM. High-density nucleosome occupancy map of human chromosome 9p21-22 reveals chromatin organization of the type I interferon gene cluster. J Interferon Cytokine Res. 2014 Sep;34(9):676-85. doi: 10.1089/jir.2013.0118. Epub 2014 Mar 27. PubMed PMID: 24673249; PubMed Central PMCID: PMC4150395.
- Bruns AM, Pollpeter D, Hadizadeh N, Myong S, Marko JF, Horvath CM. ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). J Biol Chem. 2013 Jan 11;288(2):938-46. doi: 10.1074/jbc.M112.424416. Epub 2012 Nov 26. PubMed PMID: 23184951; PubMed Central PMCID: PMC3543043.